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- Title
Antibacterial and Anti-Inflammatory Properties of Peptide KN-17.
- Authors
Zhang, Qian; Yu, Shuipeng; Hu, Meilin; Liu, Zhiyang; Yu, Pei; Li, Changyi; Zhang, Xi
- Abstract
Peri-implantitis, an infectious disease originating from dental biofilm that forms around dental implants, which causes the loss of both osseointegration and bone tissue. KN-17, a truncated cecropin B peptide, demonstrated efficacy against certain bacterial strains associated with peri-implantitis. This study aimed to assess the antibacterial and anti-inflammatory properties and mechanisms of KN-17. The effects of KN-17 on oral pathogenic bacteria were assessed by measuring its minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Moreover, the cytotoxicity and anti-inflammatory effects of KN-17 were evaluated. KN-17 inhibited the growth of Streptococcus gordonii and Fusobacterium nucleatum during in vitro biofilm formation and possessed low toxicity to hBMSCs cells. KN-17 also caused RAW264.7 macrophages to transform from M1 to M2 by downregulating pro-inflammatory and upregulating anti-inflammatory factors. It inhibited the NF-κB signaling pathway by reducing IκBα and P65 protein phosphorylation while promoting IκBα degradation and nuclear P65 translocation. KN-17 might be an efficacious prophylaxis against peri-implant inflammation.
- Subjects
PEPTIDES; DENTAL implants; ANTIMICROBIAL peptides; PERI-implantitis; PATHOGENIC bacteria; STREPTOCOCCUS mutans
- Publication
Microorganisms, 2022, Vol 10, Issue 11, p2114
- ISSN
2076-2607
- Publication type
Article
- DOI
10.3390/microorganisms10112114