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- Title
Investigation of galectin-3 levels in diabetic foot ulcers.
- Authors
Gunes, Ali Erdal; Eren, Mehmet Ali; Koyuncu, Ismail; Taskin, Abdullah; Sabuncu, Tevfik
- Abstract
Objective: It has been shown that galectin-3 (Gal-3) promotes angiogenesis and new vessel formation. Serum Gal-3 is a risk factor for vascular complications in type 2 diabetes. The aim of this study is to compare Gal-3 levels with a range of biochemical parameters. Method: A prospective study consisted of individuals as a control group (group 1), patients diagnosed with type 2 diabetes without DFUs (group 2), and patients with type 2 diabetes with a DFU (group 3). Patient levels of endothelin-1 (ET-1), vascular endothelial growth factor-A (VEGF-A), nitric oxide (NO), and Gal-3 were measured. Results: In total, 91 patients participated, (28 male, 63 female with a mean age of 55.83±6.35 years) Mean ET-1 (39.0±16.9), NO (17.6±7.6), VEGF-A (33.5±13.4) and Gal-3 (535.1±420.5) levels were significantly higher in group 3 compared with the other two groups (p<0.01). Furthermore, the Gal-3 level was positively and statistically significantly correlated with C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), ET-1 and NO levels in all groups. Conclusion: In our study, the level of Gal-3 was shown to be positively correlated with the VEGF-A level. Hence, Gal-3 can be considered as a defence mechanism against complications of diabetes, thus contributing to wound healing. Gal-3 may play a critical role in DFU formation and progression. Moreover, it could be suggested that Gal-3 may give an indication of prognosis, as it elevates VEGF-A levels and stimulates angiogenesis. Further studies are required to confirm the findings of this study.
- Subjects
TURKEY; BLOOD sedimentation; C-reactive protein; CHI-squared test; ENDOTHELINS; ENZYME-linked immunosorbent assay; LONGITUDINAL method; NITRIC oxide; TYPE 2 diabetes; PROTEINS; STATISTICS; T-test (Statistics); DATA analysis; DIABETIC foot; ENDOTHELIAL growth factors; DATA analysis software; ONE-way analysis of variance
- Publication
Journal of Wound Care, 2018, Vol 27, Issue 12, p843
- ISSN
0969-0700
- Publication type
Article
- DOI
10.12968/jowc.2018.27.12.843