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- Title
A Coumarin-Based Fluorescent Probe for Selective Detection of Cu(II) and Imaging in Human Cell.
- Authors
Gao, Shan; Wang, Ai-Ling; Wang, Ming-Zhe
- Abstract
A novel coumarin-derived Schiff base fluorescent probe was reported to detect Cu2+ ions in human cells. It was synthesized by the reaction between 7-(diethylamino)coumarin-3-carbohydrazide and pyridoxal 5′-phosphate. The probe has good stability and it exhibited obviously decreasing fluorescent response at λ 490 nm upon addition of Cu(II) ions. The fluorescent probe showed high selectivity for Cu(II) ions compared to other metal ions. The probe has been successfully applied to detect Cu(II) ions in human cells.
- Subjects
FLUORESCENT probes; COPPER; CELL imaging; SCHIFF bases; METAL ions; INTRAMOLECULAR proton transfer reactions
- Publication
Russian Journal of Organic Chemistry, 2024, Vol 60, Issue 3, p467
- ISSN
1070-4280
- Publication type
Article
- DOI
10.1134/S107042802403014X