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- Title
Cardiovascular response to exercise training in the systemic right ventricle of adults with transposition of the great arteries.
- Authors
Shafer, K. M.; Janssen, L.; Carrick‐Ranson, G.; Rahmani, S.; Palmer, D.; Fujimoto, N.; Livingston, S.; Matulevicius, S. A.; Forbess, L. W.; Brickner, B.; Levine, B. D.
- Abstract
Key Points Patients with transposition of the great arteries (TGA) and systemic right ventricles have premature congestive heart failure; there is also a growing concern that athletes who perform extraordinary endurance exercise may injure the right ventricle., Therefore we felt it essential to determine whether exercise training might injure a systemic right ventricle which is loaded with every heartbeat., Previous studies have shown that short term exercise training is feasible in TGA patients, but its effect on ventricular function is unclear., We demonstrate that systemic right ventricular function is preserved (and may be improved) in TGA patients with exercise training programmes that are typical of recreational and sports participation, with no evidence of injury on biomarker assessment., Stroke volume reserve during exercise correlates with exercise training response in our TGA patients, identifying this as a marker of a systemic right ventricle (SRV) that may most tolerate (and possibly even be improved by) exercise training. , Abstract We aimed to assess the haemodynamic effects of exercise training in transposition of the great arteries (TGA) patients with systemic right ventricles (SRVs). TGA patients have limited exercise tolerance and early mortality due to systemic (right) ventricular failure. Whether exercise training enhances or injures the SRV is unclear. Fourteen asymptomatic patients (34 ± 10 years) with TGA and SRV were enrolled in a 12 week exercise training programme (moderate and high-intensity workouts). Controls were matched on age, gender, BMI and physical activity. Exercise testing pre- and post- training included: (a) submaximal and peak; (b) prolonged (60 min) submaximal endurance and (c) high-intensity intervals. Oxygen uptake (
- Subjects
EXERCISE; PHYSICAL fitness research; TRANSPOSITION of great vessels; PULMONARY artery abnormalities; ATHLETES' health
- Publication
Journal of Physiology, 2015, Vol 593, Issue 11, p2447
- ISSN
0022-3751
- Publication type
Article
- DOI
10.1113/JP270280