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- Title
Bone healing in critical-size defects treated with bioactive glass/calcium sulfate: a histologic and histometric study in rat calvaria.
- Authors
Furlaneto, Flávia A. C.; Nagata, Maria J. H.; Fucini, Stephen E.; Deliberador, Tatiana M.; Okamoto, Tetuo; Messora, Michel R.
- Abstract
Objective: The purpose of this study was to analyze histologically the influence of bioactive glass (BG) with or without a calcium sulfate (CS) barrier on bone healing in surgically created critical-size defects (CSD) in rat calvaria. Material and methods: A CSD was made in each calvarium of 48 rats. They were divided into three groups: C (control): blood clot only; BG: defect filled with BG; and BG/CS: defect filled with BG covered by a CS barrier. Animals were euthanized at 4 or 12 weeks. Formation of new bone was evaluated histomorphometrically. Results: No defect completely regenerated with bone. BG particles were observed in Groups BG and BG/CS at both periods of analysis. The thickness throughout the healing area in Groups BG and BG/CS was similar to the original calvarium, while Group C presented a thin connective tissue in the center of the defect in both periods of analysis. At 4 weeks, Groups C and BG/CS presented significantly more bone formation than Group BG. No significant differences were found between Groups C and BG/CS. At 12 weeks, no significant differences in the amount of bone formation were observed among the three groups. When comparing 4 and 12 weeks, there was a significant increase in new bone formation within groups BG and BG/CS, but not C. Conclusion: BG particles, used with or without a CS barrier, maintained the volume and contour of the area grafted in CSD. However, they did not lead to a significant difference in bone formation when compared with control at 12 weeks post-operative.
- Subjects
BONES; WOUND healing; ARTIFICIAL implant complications; BIOACTIVE compounds; CALCIUM sulfate; BONE regeneration
- Publication
Clinical Oral Implants Research, 2007, Vol 18, Issue 3, p311
- ISSN
0905-7161
- Publication type
Article
- DOI
10.1111/j.1600-0501.2006.01331.x