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- Title
Clinical profile, treatment, and outcomes of patients with mantle cell lymphoma treated in a tertiary care center in South India.
- Authors
Lokesh, Kadabur Nagendrappa; Garg, Sunny; Kuntegowdanahalli, Lakshmaiah Chinnagiriyappa; Kanakasetty, Govinda Babu; Srinivasamurthy, Premalata Chennagiri; Rao, Suparna Ajit; Jacob, Linu Abraham; Dasappa, Loknatha; Chikkadasappa, Suresh Babu Mallekavu; Halleshappa, Rudresha Antapura; Krishnappa, Rajeev Lakkavalli
- Abstract
Introduction: Mantle cell lymphoma has an aggressive course, with unfavorable outcomes. Subjects and Methods: A retrospective analysis was undertaken and 77 cases were identified between 2009 and 2014. Results: Median age was 55 years with a male to female ratio of 6:1. Patients with pure nodal disease at presentation were fewer than with extranodal disease (53.2%). Most common extranodal site was bone marrow. A number of patients with low-, low-intermediate, high-intermediate, and high-risk International Prognostic Index (IPI) scores were 6, 24, 22, and 25. Treatment consisted of cyclophosphamide, hydroxydaunorubicin, oncovin, prednisolone (CHOP) or R-CHOP regimens. Median survival was 21 months. Median overall survival with early and advanced disease was 31 and 18 months (P = 0.02). Patients who received R-CHOP survived better than those given CHOP, 30 and 16 months (P = 0.0002). There was no difference in survival with respect to age, gender, extranodal, or bone marrow involvement. Conclusions: Most patients presented with extranodal disease, advanced stage, and high IPI. Although rituximab has improved survival, intensive chemotherapy would be required to improve survival.
- Subjects
INDIA; MANTLE cell lymphoma; TREATMENT effectiveness; ANTHRACYCLINES; CANCER chemotherapy; TERTIARY care; CANCER genetics; PUBLIC health; THERAPEUTICS
- Publication
Clinical Cancer Investigation Journal, 2016, Vol 5, Issue 5, p369
- ISSN
2278-1668
- Publication type
Article
- DOI
10.4103/2278-0513.197863