We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cerebrospinal Fluid Biomarkers in Parkinson's Disease: A Critical Overview of the Literature and Meta-Analyses.
- Authors
Katayama, Takayuki; Sawada, Jun; Takahashi, Kae; Yahara, Osamu
- Abstract
Parkinson's disease (PD) is a common neurodegenerative disorder; however, well-established biochemical markers have not yet been identified. This review article covers several candidate cerebrospinal fluid (CSF) biomarkers for PD based on the recent literature and meta-analysis data. The decrease of α-synuclein in PD is supported by meta-analyses with modest reproducibility, and a decrease of amyloid β42 is seen as a prognostic marker for cognitive decline. Tau, phosphorylated tau (p-tau), and neurofilament light chains have been used to discriminate PD from other neurodegenerative disorders. This article also describes more hopeful biochemical markers, such as neurotransmitters, oxidative stress markers, and other candidate biomarkers.
- Subjects
PARKINSON'S disease; CEREBROSPINAL fluid; BIOMARKERS; NEURODEGENERATION; OXIDATIVE stress
- Publication
Brain Sciences (2076-3425), 2020, Vol 10, Issue 7, p466
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci10070466