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- Title
Primary peritoneal low‐grade serous carcinoma detected in cervical smear: Pitfalls mitigated by clinicocytopathologic clues and cellblock immunocytochemistry.
- Authors
AbdullGaffar, Badr; Raman, Lakshmiah G.; Ahmad, Zulfiqar
- Abstract
This article discusses the detection of primary peritoneal low-grade serous carcinoma in cervical smears. The study reports three cases of asymptomatic women who had abnormal glandular cells in routine Pap smears. Further investigations revealed raised serum CA125 levels and mild ascitic fluid collection in the pelvis. The patients underwent exploratory laparotomy, which confirmed the presence of low-grade serous carcinoma. The article emphasizes the diagnostic value of cellblock immunocytochemistry in confirming the diagnosis. The document also discusses the presence of low-grade serous papillary cell clusters with psammoma bodies in the tubal lumen, which are characteristic of primary peritoneal serous tumors. The document highlights the importance of considering various factors to distinguish primary peritoneal serous carcinomas from other types of serous tumors. The shedding of peritoneal tumor cells into the uterine cavity is proposed as a possible explanation for abnormal Pap tests.
- Subjects
FALLOPIAN tubes; ENDOMETRIUM; HUMAN papillomavirus; IMMUNOCYTOCHEMISTRY; BREAST; CARCINOMA; PAP test
- Publication
Cytopathology, 2024, Vol 35, Issue 4, p503
- ISSN
0956-5507
- Publication type
Article
- DOI
10.1111/cyt.13380