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- Title
Association of serum fetuin-A with carotid arterial stiffness.
- Authors
Mori, Katsuhito; Emoto, Masanori; Araki, Takahiro; Yokoyama, Hisayo; Teramura, Megumi; Lee, Eiko; Motoyama, Koka; Koyama, Hidenori; Shoji, Tetsuo; Inaba, Masaaki; Nishizawa, Yoshiki
- Abstract
Objective Fetuin-A is a circulating glycoprotein which is well characterized as an inhibitor of ectopic calcification. Vascular calcification commonly found in chronic kidney disease (CKD) patients is a predictor of cardiovascular death. Recently, several groups have demonstrated that low fetuin-A levels are associated with mortality in uraemic patients, possibly through regulation of vascular calcification. However, the physiological significance of fetuin-A in atherosclerosis remains unknown, except in specific conditions, such as vascular calcification in CKD patients. The objective of this study was to investigate the association between serum fetuin-A levels and arterial stiffness, a functional property of atherosclerosis, in healthy subjects. Patients and measurements The study subjects comprised 141 healthy subjects. We measured serum fetuin-A levels and stiffness parameter β for the common carotid artery, which was assessed by ultrasound using a phase-locked echo-tracking system. Results Simple regression analyses indicated that serum fetuin-A levels were significantly correlated with stiffness parameter β ( r = 0·200, P = 0·018). Multiple regression analyses showed that, besides age, fetuin-A (β = 0·166, P = 0·033) independently contribute to the stiffness parameter β ( R2 = 0·310, P < 0·0001). Conclusions Serum fetuin-A level is associated with carotid arterial stiffness, independent of known atherogenic factors in healthy subjects.
- Subjects
ALPHA fetoproteins; SERUM; CAROTID artery diseases; CHRONIC kidney failure; ATHEROSCLEROSIS; KIDNEY diseases
- Publication
Clinical Endocrinology, 2007, Vol 66, Issue 2, p246
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1111/j.1365-2265.2006.02716.x