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- Title
FSH and ovarian response: spontaneous recovery of pituitary–ovarian activity during the pill-free period vs . exogenous recombinant FSH during high-dose combined oral contraceptives.
- Authors
van Heusden, A. M; Coelingh Bennink, H. J. T; Fauser, B. C. J. M
- Abstract
Summary ojbective Compare spontaneous recovery of pituitary–ovarian activity during the pill-free period following the correct use of low-dose oral contraceptives and subsequent ovarian function during the administration of exogenous recombinant FSH (recFSH) after switching to continued Lyndiol® (2·5 mg lynestrenol + 0·05 mg ethinyl-oestradiol) medication. design Prospective, randomized, group-comparative, single-centre study. Following the monitoring of the pill-free period (week 1) and subsequent treatment with Lyndiol® (for a total of 5 weeks), all subjects were randomly allocated to one of four groups receiving daily FSH injections for 1 week [75, 150, 225 IU recFSH or 150 IU purified urinary FSH (uFSH)] during the fourth week of Lyndiol® use. patients Thirty-six healthy volunteers aged 18–39 years, prestudy oral contraceptive use for at least 3 months, cycle length between 24 and 35 days. measurements Serum FSH, LH and oestradiol (E2 ) concentrations as well as transvaginal ultrasound assessment of the number and diameter of follicles > 2 mm were used to monitor pituitary ovarian function. results At the start of the pill-free period following the prestudy contraceptive medication, 67% of the women presented with LH and FSH levels < 1 IU/l and only one follicle > 10 mm was observed. Initial levels of LH and FSH correlated (P < 0·05) with the extent of pituitary–ovarian activity during the pill-free period. At the end of the pill-free period a follicle > 10 mm had emerged in one subject only. During the first 3 days of Lyndiol® use, seven women (19%) eventually showed at least one follicle > 10 mm. During combined exogenous FSH and Lyndiol® administration, LH levels remained completely suppressed (≤ 0·5 IU/l) in all women studied. FSH levels and number and size of follicles increased with increasing doses of exogenous...
- Subjects
PITUITARY gland; FOLLICLE-stimulating hormone; LUTEINIZING hormone
- Publication
Clinical Endocrinology, 2002, Vol 56, Issue 4, p509
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1046/j.1365-2265.2002.01518.x