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- Title
Dose response with fluticasone propionate on adrenocortical activity and recovery of basal and stimulated responses after stopping treatment.
- Authors
Wilson, Andrew M.; Sims, Erika J.; Lipworth, Brian J.; Lipworth
- Abstract
OBJECTIVETo evaluate the dose–response relationship for adrenocortical activity with fluticasone propionate (FP) and to assess basal and dynamic markers after stopping treatment for 3 days. PATIENTS AND DESIGNFourteen asthmatic patients were recruited: mean age 33.3 years, forced expiratory volume in 1 s (FEV1): 91.3% predicted, forced mid expiratory flow rate (FEF25–75): 58.1% predicted. A single blind study design was used comparing a placebo run-in with sequentially low, medium and high doses of FP and a placebo washout. All active treatments, placebo and washout were each for 3 days. FP was given at steady-state with twice daily divided dosing at 0800 h and 2200 h at doses of 375 μg, 875 μg, and 1750 μg per day. MEASUREMENTSA 100 μg iv bolus hCRF test was performed at 0800h after the run-in and washout periods. Blood samples were taken for 0800h serum cortisol and osteocalcin as well as an overnight 10 h urine collection for cortisol/creatinine excretion after the run-in period, each dose of active treatment and washout. RESULTSFor serum cortisol (pre and post hCRF stimulation) there was no significant difference between placebo and washout values. Mean (SE) cortisol (nmol/1) values pre hCRF were run-in: 644.5 (59.7), washout: 550.3 (42.8) and post hCRF were run-in: 690.9 (42.9), washout: 719.1 (43.8). There was a significant (P < 0.05) difference between run-in vs medium and high doses for 0800 h serum cortisol, overnight urinary cortisol and overnight urinary cortisol/creatinine excretion; and vs high dose for serum osteocalcin. The fold difference (95% CI for difference) between run-in and high dose was: 2.2 (1.5–3.2) for overnight urinary cortisol, 2.5 (1.5–4.1) for overnight urinary cortisol/creatinine, 2.0 (1.1–3.6) for serum cortisol, and 1.2 (1.1–1.3) for serum osteocalcin. CONCLUSIONFluticasone propionate exhibited dose related adrenal suppression with treatment. The...
- Subjects
PROPIONATES; DOSE-response relationship in biochemistry; ADRENOCORTICAL hormones; PHYSIOLOGY
- Publication
Clinical Endocrinology, 1999, Vol 50, Issue 3, p329
- ISSN
0300-0664
- Publication type
Article
- DOI
10.1046/j.1365-2265.1999.00652.x