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- Title
Genetically modified immunocompetent cells in HIV infection.
- Authors
Palù, G; Pira, GLi; Gennari, F; Fenoglio, D; Parolin, C; Manca, F
- Abstract
Even in the era of highly active antiretroviral therapy (HAART), gene therapy (GT) can remain a promising approach for suppressing HIV infection, especially if complemented with other forms of pharmacological and immunological intervention. A large number of vectors and targets have been studied. Here we discuss the potential of genetically treated, antigen-specific immunocompetent cells for adoptive autologous immunotherapy of HIV infection. Cellu- lar therapies with gene-modified CD8 and CD4 lymphocytes are aimed at reconstituting the antigen-specific repertoires that may be deranged as a consequence of HIV infection. Even if complete eradication of HIV from the reservoirs cannot be achieved, reconstitution of cellular immunity specific for opportunistic pathogens and for HIV itself is a desirable option to control progression of HIV infection and AIDS pathogenesis better.
- Subjects
GENE therapy; HIV infections; IMMUNOCOMPETENT cells; IMMUNOTHERAPY
- Publication
Gene Therapy, 2001, Vol 8, Issue 21, p1593
- ISSN
0969-7128
- Publication type
Article