We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
A REVIEW ON SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM.
- Authors
Vilas, Pathak Chirag; Gujarathi, Nayan A.; Rane, Bhushan R.; Pawar, Sunil P.
- Abstract
Oral route is one of the most patient friendly routes for the most of the pharmacologically chronic disease treatment. Nearly 40% of new drug candidates exhibit low water solubility and hence high intra- and inter-subject variability and lack of dose proportionality. Much attention has been given to lipid-based formulation with particular emphasis on self-micro emulsifying drug delivery system to improve the oral bioavailability of lipophilic drugs. It requires small amount of dose and also drugs can be protected from hostile environment in gut. Self micro emulsifying drug delivery systems are specialized form of delivery system in which drug is encapsulated in a lipid base with or without pharmaceutical acceptable surfactant. Self micro emulsifying drug delivery systems are isotropic mixtures of oil, surfactant, co-surfactant and drug with a unique ability to form fine oil in water micro emulsion upon mild agitation following dilution with aqueous phase. SMEDDS is evaluated by various methods like visual assessment, droplet polarity and droplet size, size of emulsion droplet, dissolution test, and charge of oil droplets, viscosity determination, and in-vitro diffusion study. With future development of this technology, SMEDDS will continue to enable novel applications in drug delivery and solve problems associated with the delivery of poorly soluble drugs.
- Subjects
CHRONIC disease treatment; ORAL drug administration; ORAL medicine; DRUG administration; DRUG development
- Publication
Pharma Science Monitor, 2013, Vol 4, Issue 1, p3628
- ISSN
0976-9242
- Publication type
Article