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- Title
PHYTOCHEMICAL EVALUATION OF AERIAL PART OF LEPTADENIA RETICULATA (Retz) FOR POLYPHENOLIC COMPOUND AND FREE RADICAL SCAVENGING ACTIVITY.
- Authors
Sonara, G. B.; Saralaya, M. G.; Gheewala, N. K.
- Abstract
Phytochemical evaluation of aerial part of Leptadenia reticulata (Retz) for poly phenolic compound and free scavenging activity. Thus to determination the Total Phenolic Content (TPC) quantified by Folin-Ciocalteu method and free radical scavenging (antioxidant) activity by in LRUSM & Acetone Extract (LRA) & methanolic (LRM) and aqueous (LRAQ) extracts of Aerial part of the Leptadenia reticulata (Retz),. Currently, there has been an increased interest globally to identify antioxidant compounds that are pharmacologically potent and have low or no side effects for use in preventive medicine in number of degenerative diseases. Total Phenolic content was found to be 2.77 % w/w in LRM & 1.33 % w/w in LRA eq Gallic acid and total flavanoid content was found to be 3.21% w/w eq. to quarcetin in LRM. (IC50) was calculated from the graph plotting inhibition percentage against extract concentration .indicated that the extracts (LRM, LRA & LRUSM) of Leptadenia reticulata have notably reduced the stable free radical of DPPH (Graph 2, 3, 4 and5) to the yellow-colored Diphenylpicrylhydrazyl with an IC50 values 56.66 ìg/ml, 55.55 ìg/ml and 47.20 ìg/ml respectively comparison with Ascorbic acid (Vitamin-C) (IC50 = 40.70 ìg/ml) And BHA( IC50 = 61.74ìg/ml). Free radical activity of various extract of Leptadenia reticulata is due to present of polyphenolic compound present in LRUSM and LRM.
- Subjects
ASCLEPIADOIDEAE; HERBAL medicine; PHENOLS; ANTIOXIDANTS; PREVENTIVE medicine; THERAPEUTICS
- Publication
Pharma Science Monitor, 2013, Vol 4, Issue 1, p3418
- ISSN
0976-9242
- Publication type
Article