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- Title
Changes of Langerhans cells during skin ageing.
- Authors
Zegarska, Barbara; Pietkun, Katarzyna; Giemza-Kucharska, Paulina; Zegarski, Tomasz; Nowacki, Maciej S.; Romańska-Gocka, Krystyna
- Abstract
Introduction: During the process of skin ageing, changes occur in all skin layers and all cells, including the Langerhans cells. Aim: To assess whether any quantitative difference in the number of CD1a+ LC cells/mm2 and HLA-DR+ LC cells/mm² as well as in their morphological features can be observed during the course of different types of skin ageing. Material and methods: The study was conducted in a group of 60 women, which was divided into three independent groups: group I with symptoms of menopausal skin ageing, group II with symptoms of photoageing, group III with symptoms of chronological ageing. Skin biopsy samples were taken from the pre-auricular region from all of the participants. The number of CD1a+ LC cells/mm² and HLA-DR+ LC cells/mm² as well as their morphological features were evaluated. Results: The frequency of CD1a+ LC and HLA-DR+ LC in all the studied groups was diverse. In groups I and III, the LC with large cell bodies and long, multi-branched processes were the majority. In group II, the LC had small cell bodies and their processes were mainly short and unbranched. Conclusions: The obtained results indicate the presence of quantitative and morphological changes of the CD1a+ LC and HLA-DR+ LC during the course of different types of skin ageing.
- Subjects
SKIN aging; LANGERHANS cells; CHRONOLOGY; SKIN biopsy; MENOPAUSE
- Publication
Advances in Dermatology & Allergology / Postępy Dermatologii i Alergologii, 2017, Vol 34, Issue 3, p260
- ISSN
1642-395X
- Publication type
Article
- DOI
10.5114/ada.2017.67849