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- Title
CD8<sup>+</sup> T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy.
- Authors
Kaushik, Abhinav; Dunham, Diane; Han, Xiaorui; Do, Evan; Andorf, Sandra; Gupta, Sheena; Fernandes, Andrea; Kost, Laurie Elizabeth; Sindher, Sayantani B.; Yu, Wong; Tsai, Mindy; Tibshirani, Robert; Boyd, Scott D.; Desai, Manisha; Maecker, Holden T.; Galli, Stephen J.; Chinthrajah, R. Sharon; DeKruyff, Rosemarie H.; Manohar, Monali; Nadeau, Kari C.
- Abstract
While food allergy oral immunotherapy (OIT) can provide safe and effective desensitization (DS), the immune mechanisms underlying development of sustained unresponsiveness (SU) following a period of avoidance are largely unknown. Here, we compare high dimensional phenotypes of innate and adaptive immune cell subsets of participants in a previously reported, phase 2 randomized, controlled, peanut OIT trial who achieved SU vs. DS (no vs. with allergic reactions upon food challenge after a withdrawal period; n = 21 vs. 30 respectively among total 120 intent-to-treat participants). Lower frequencies of naïve CD8+ T cells and terminally differentiated CD57+CD8+ T cell subsets at baseline (pre-OIT) are associated with SU. Frequency of naïve CD8+ T cells shows a significant positive correlation with peanut-specific and Ara h 2-specific IgE levels at baseline. Higher frequencies of IL-4+ and IFNγ+ CD4+ T cells post-OIT are negatively correlated with SU. Our findings provide evidence that an immune signature consisting of certain CD8+ T cell subset frequencies is potentially predictive of SU following OIT. Oral immunotherapy (OIT) clinical trials have helped a subset of participants achieve sustained unresponsiveness (SU) to the cognate allergen. Here the authors analyse immune cells from participants from one peanut OIT trial and show that CD8+ T cell differentiation status at baseline may help to predict the likelihood of achieving SU.
- Subjects
T cell differentiation; IMMUNOGLOBULIN E; T cells; IMMUNOTHERAPY; CYTOTOXIC T cells; FOOD allergy; ALLERGIES
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-34222-8