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- Title
Clinical phenotypes and outcomes associated with SARS-CoV-2 variant Omicron in critically ill French patients with COVID-19.
- Authors
de Prost, Nicolas; Audureau, Etienne; Heming, Nicholas; Gault, Elyanne; Pham, Tài; Chaghouri, Amal; de Montmollin, Nina; Voiriot, Guillaume; Morand-Joubert, Laurence; Joseph, Adrien; Chaix, Marie-Laure; Préau, Sébastien; Favory, Raphaël; Guigon, Aurélie; Luyt, Charles-Edouard; Burrel, Sonia; Mayaux, Julien; Marot, Stéphane; Roux, Damien; Descamps, Diane
- Abstract
Infection with SARS-CoV-2 variant Omicron is considered to be less severe than infection with variant Delta, with rarer occurrence of severe disease requiring intensive care. Little information is available on comorbid factors, clinical conditions and specific viral mutational patterns associated with the severity of variant Omicron infection. In this multicenter prospective cohort study, patients consecutively admitted for severe COVID-19 in 20 intensive care units in France between December 7th 2021 and May 1st 2022 were included. Among 259 patients, we show that the clinical phenotype of patients infected with variant Omicron (n = 148) is different from that in those infected with variant Delta (n = 111). We observe no significant relationship between Delta and Omicron variant lineages/sublineages and 28-day mortality (adjusted odds ratio [95% confidence interval] = 0.68 [0.35–1.32]; p = 0.253). Among Omicron-infected patients, 43.2% are immunocompromised, most of whom have received two doses of vaccine or more (85.9%) but display a poor humoral response to vaccination. The mortality rate of immunocompromised patients infected with variant Omicron is significantly higher than that of non-immunocompromised patients (46.9% vs 26.2%; p = 0.009). In patients infected with variant Omicron, there is no association between specific sublineages (BA.1/BA.1.1 (n = 109) and BA.2 (n = 21)) or any viral genome polymorphisms/mutational profile and 28-day mortality. SARS-CoV-2 variant Omicron has been suggested to cause less severe disease. This prospective study shows that the clinical phenotype in patients infected with Omicron differs from patients infected with Delta but no association between Delta and Omicron including sublineages and mortality was observed.
- Subjects
FRANCE; SARS-CoV-2 Omicron variant; COVID-19; SARS-CoV-2 Delta variant; CRITICALLY ill; INTENSIVE care units; NOSOCOMIAL infections
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-33801-z