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- Title
Variation in the fruit development gene POINTED TIP regulates protuberance of tomato fruit tip.
- Authors
Song, Jianwen; Shang, Lele; Li, Changxing; Wang, Wenqian; Wang, Xin; Zhang, Chunli; Ai, Guo; Ye, Jie; Yang, Changxian; Li, Hanxia; Hong, Zonglie; Larkin, Robert M.; Ye, Zhibiao; Zhang, Junhong
- Abstract
The domestication of tomato has led to striking variations in fruit morphology. Here, we show a genome-wide association study (GWAS) to understand the development of the fruit tip and describe a POINTED TIP (PT) gene that encodes a C2H2-type zinc finger transcription factor. A single nucleotide polymorphism is found to change a histidine (H) to an arginine (R) in the C2H2 domain of PT and the two alleles are referred to as PTH and PTR. Knocking out PTH leads to development of pointed tip fruit. PTH functions to suppress pointed tip formation by downregulating the transcription of FRUTFULL 2 (FUL2), which alters the auxin transport. Our evolutionary analysis and previous studies by others suggest that the PTR allele likely hitch-hiked along with other selected loci during the domestication process. This study uncovers variation in PT and molecular mechanism underlying fruit tip development in tomato. While auxin has been implicated in the development of tomato fruit with pointed tips, the mechanism are largely unknown. Here, the authors report variation of a C2H2-type zinc finger transcription factor affects transcription of FUL2, which consequently regulates auxin transport and distribution to determine tomato fruit shape.
- Subjects
FRUIT development; FRUIT ripening; SINGLE nucleotide polymorphisms; TOMATOES; FRUIT; GENOME-wide association studies; DOMESTICATION of animals
- Publication
Nature Communications, 2022, Vol 13, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-022-33648-4