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- Title
BIOLOGICAL ACTIVITY OF FLUORESCENT COPPER COMPLEX: SYNTHESIS, CRYSTAL STRUCTURE, DFT AND PROTEIN BINDING STUDY.
- Authors
Sahoo, Gobinda Prasad; Pandey, Akhil; Hazra, Madhumita; Patra, Animesh
- Abstract
Synthesis of square planar copper (II) complex with formula [Cu (DMAP)2(NCS)2] (1) (DMAP =N,N-dimethyl-4 aminopyridine) was done and characterized by various spectroscopic and single-crystal X-ray diffraction study. Complex 1 crystallizes in the monoclinic space group, P 21/c, with cell dimensions a = 6.066(2), b = 10.702(4), c = 14.561(5) Å, a = 90 b = 93.11(2) and c = 90. The electron transfer mechanism of copper (II) complex was measured by cyclic voltammetry and indicate copper (II) complex is the Cu(II)/Cu(I) couple. The electronic structure and spectral properties of the complex-1 has been explained by density functional theory (DFT) and time dependent density functional theory (TDDFT) calculations. In-vitro, human serum albumin (HSA) binding was also carried out using absorption and fluorescence technique, which showed considerable binding affinities of the complex with HSA. Again we report the synthesis of copper complex-HSA microcrystals. The complex has been screened for antimicrobial activity by agar disk diffusion and minimum inhibitory concentration (MIC) strain against some pathogenic bacteria.
- Subjects
CRYSTAL structure; PROTEIN binding
- Publication
Journal of Advanced Scientific Research, 2021, Vol 12, Issue 1, p200
- ISSN
0976-9595
- Publication type
Article