We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Is There a Limitation of RECIST Criteria in Prediction of Pathological Response, in Head and Neck Cancers, to Postinduction Chemotherapy?
- Authors
Patil, V.; Noronha, V.; Joshi, A.; Muddu Krishna, Vamshi; Juvekar, S.; Pantvaidya, Gauri; Chaturvedi, Pankaj; Chaukar, D.; Arya, Supreeta; Patil, Aswari; Bhosale, B.; Dongre, A.; Dcruz, A. K.; Prabhash, K.
- Abstract
This study studied the coorelation between radiological response to induction chemotherapy and achievement of pCR or near pCR. It was a retrospective analysis in which all patients who received NACT from 2008 till april 2012 were subjected to inclusion criteria. Coorelation analysis was performed between CR + PR and achievement of pCR or near pCR. Twenty four patients were identified. The primary site of tumor was oral cavity in 19 patients (79.2%), maxilla in 2 patients (4.2%), laryngopharynx in 2 patients (4.2%) and oropharynx in 1 patient (4.2%). The clinical stage was stage IVA in 16 patients (66.7%) and IVB in 8 patients (33.3%). The overall response rates ie a combination of CR and PR was seen in 11 patients (45.8%). The pCR was seen in 15 patients (62.5%) and rest had near pCR. There was no linear coorelation between radiological size decrement and tumor response. On coorelation analysis the spearman correlation coefficient was -0.039 (P = 0.857). This suggest that presently used radiological response criterias for response assessment in head and neck cancers severely limit our ability to identify patients who would have pCR or near pCR.
- Subjects
INDIA; HEAD tumors; NECK tumors; ACADEMIC medical centers; COMBINED modality therapy; MEDICAL records; STATISTICS; DATA analysis; RETROSPECTIVE studies; DATA analysis software; PROGNOSIS
- Publication
ISRN Oncology, 2013, p1
- ISSN
2090-5661
- Publication type
Article
- DOI
10.1155/2013/259154