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- Title
Silencing SOX11 Alleviates Allergic Rhinitis by Inhibiting Epithelial-Derived Cytokines.
- Authors
Li Jiang; Chunrui Wang; Rui Zhao; Jing Cao; Yaohui Liu; Linli Tian; Ming Liu
- Abstract
Background: Allergic rhinitis is a chronic inflammatory disease of the nasal mucosa affecting the quality of life of patients. SRY-box transcription factor 11 (SOX11) was reported to play important roles in inflammatory responses, but its role in AR is poorly understood. Aims: To explore the role of SOX11 in the development of allergic rhinitis. Study Design: Cell culture and animal study. Methods: An in vivo murine allergic rhinitis model was established using ovalbumin treatment in female mice. Interleukin-13-stimulated human nasal mucosa epithelial cells were used for in vitro studies. Expression levels of SOX11, epithelial-derived cytokines, and mucin were determined in both modesls. Results: SOX11 was highly expressed in allergic rhinitis mice. Allergy symptoms, serum ovalbumin-specific IgE, histamine, eosinophils, goblet cells, and type 2 cytokine secretion were increased in ovalbumin-treated mice. Furthermore, allergic rhinitis mice exhibited overproduction of epithelial-derived cytokines (thymic stromal lymphopoietin, interleukin-25, interleukin-33), C-C motif chemokine ligand 26 (CCL26), and mucin 5 AC (MUC5AC). Silencing SOX11 alleviated the behavioral symptoms and upregulation of epithelial-derived cytokines, CCL26, and MUC5AC. In human nasal mucosa epithelial cells, interleukin-13 enhanced SOX11 expression in a time-dependent manner, and signal transducer and activator of transcription 6 (STAT6) was involved in the interleukin-13-mediated expression of SOX11 by regulating transcription. Knockdown of SOX11 reduced epithelial-derived cytokine expression and MUC5AC levels in interleukin-13-treated human nasal mucosa epithelial cells. Conclusion: SOX11 plays a critical role in allergic rhinitis development by regulating epithelial-derived cytokines and might be a new therapeutic target for allergic rhinitis.
- Subjects
CYTOKINES; INTERLEUKINS; IN vitro studies; BIOLOGICAL models; EOSINOPHILS; IN vivo studies; CELL culture; IMMUNOGLOBULINS; ANIMAL experimentation; RHINITIS; THYMIC stromal lymphopoietin; QUALITY of life; TRANSCRIPTION factors; EPITHELIAL cells; MICE; HISTAMINE; CARRIER proteins
- Publication
Balkan Medical Journal, 2023, Vol 40, Issue 1, p57
- ISSN
2146-3123
- Publication type
Article
- DOI
10.4274/balkanmedj.galenos.2022.2022-9-31