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- Title
Involvement of µ-opioid Receptors and κ-opioid Receptors in Itch-related Scratching Behaviour of Imiquimod-induced Psoriasis-like Dermatitis in Mice.
- Authors
Nobuaki TAKAHASHI; Mitsutoshi TOMINAGA; Ryohei KOSAKA; Yayoi KAMATA; Yoshie UMEHARA; Hironori MATSUDA; Azumi SAKAGUCHI; Hideoki OGAWA; Kenji TAKAMORI
- Abstract
The pathogenesis of psoriatic itch is poorly understood. The aim of this study was to investigate the involvement of opioid receptors in scratching behaviour of imiquimod-induced psoriasis-like dermatitis model mice. Topical application of 5% imiquimod cream to the rostral back skin of mice induced antihistamineresistant scratching behaviour. The expression of µ-opioid receptor (MOR) protein increased in the epidermis, dorsal root ganglia (DRG) and spinal cord of imiquimod-treated mice. In contrast, the expression of κ-opioid receptor (KOR) protein decreased in the DRG and spinal cord of imiquimod-treated mice, and was undetectable in the epidermis of both groups. Topical or intraperitoneal administration of the MOR antagonist naloxone and oral administration of the centrally acting KOR agonist ICI-199,441 inhibited scratching behaviour, whereas oral administration of the peripherally-selective KOR agonist asimadoline did not. These results suggest that peripheral and central MOR and central KOR may be involved in the modulation of scratching behaviour in imiquimod-treated mice.
- Subjects
ITCHING; SKIN inflammation; OPIOID receptors; PSORIASIS; DORSAL root ganglia; NALOXONE; ANTIHISTAMINES
- Publication
Acta Dermato-Venereologica, 2017, Vol 97, Issue 8, p928
- ISSN
0001-5555
- Publication type
Article
- DOI
10.2340/00015555-2704