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- Title
Antidiabetic and antihyperlipidemic activities of aqueous and ethanolic leaf extracts of Feronia limonia.
- Authors
Chowdary, P. Ranadheer; Praveen, D.; Niventhi, A.; Aanandhi, M. Vijey
- Abstract
Background: Traditional drugs can be used as a novel alternative for synthetic agents. All the synthetic agents possess risk of multiple side effects. Hence, a previously traditionally used drug, Feronia limonia is studied for its antidiabetic and antihyperlipidemic effects. Methods: Ethanolic and aqueous leaf extracts of different concentrations were tested for antidiabetic capabilities on streptozotocin (500 mg/kg I.P)-induced diabetic Swiss albino mice, fasting blood glucose, glycosylated hemoglobin, body weight, lipid profile test, and preliminary phytochemical screening for extracts were also carried out. Results: Significant antidiabetic activity characterized by significant reduction in blood glucose level and glycosylated hemoglobin was observed with ethanolic extract (200 mg/kg) at 14 days of treatment compared with glibenclamide (500 mcg/kg, I.P). Both these extracts showed significant reduction in total cholesterol, triglycerides, and lowdensity lipoproteins and also on certain liver markers. Conclusion: The study concludes that F. limonia leaf extracts show a significant antidiabetic and antihyperlipidemic activity. Hence, the constituents are isolated for further research.
- Subjects
HYPOGLYCEMIC agents; AQUEOUS solutions; DRUG utilization; PHARMACODYNAMICS; BODY weight
- Publication
Drug Invention Today, 2018, Vol 10, Issue 2, p151
- ISSN
0975-7619
- Publication type
Article