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- Title
Inactivation of DNA repair—prospects for boosting cancer immune surveillance.
- Authors
Truini, Anna; Germano, Giovanni; Bardelli, Alberto
- Abstract
The emergence of drug resistance depends on the ability of the genome of cancer cells to constantly mutate and evolve under selective pressures. The generation of new mutations is accelerated when genes involved in DNA repair pathways are altered. Notably, although the emergence of new mutations fosters drug resistance, new variants can nevertheless become novel antigens that promote immune surveillance and even restrict cancer growth.
- Subjects
DNA repair; CANCER cell analysis; GENE expression; DRUG resistance; IMMUNE system
- Publication
Genome Medicine, 2018, Vol 10, Issue 1, pN.PAG
- ISSN
1756-994X
- Publication type
Article
- DOI
10.1186/s13073-018-0603-9