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- Title
High physical fitness is associated with reduction in basal‐ and exercise‐induced inflammation.
- Authors
Kleiven, Ø.; Bjørkavoll‐Bergseth, M.; Melberg, T.; Skadberg, Ø.; Bergseth, R.; Selvåg, J.; Auestad, B.; Aukrust, P.; Aarsland, T.; Ørn, S.
- Abstract
C‐reactive protein (CRP) increases after strenuous exercise. It has been a concern that prolonged strenuous exercise may be harmful and induce a deleterious inflammatory response. The purpose of this study was to (a) assess and quantify the magnitude of CRP response following an endurance cycling competition in healthy middle‐aged recreational cyclists. (b) Identify important determinants of this response. (c) Identify the relationship between CRP, myocardial damage (cardiac Troponin I (cTnI)), and myocardial strain (B‐type natriuretic peptide [BNP]). (d) Identify the relationship between CRP and clinical events, defined as utilization of healthcare services or self‐reported unusual discomfort. Race time was used as a measure of physical fitness. A total of 97 individuals (43±10 years of age, 74 [76%] males) were assessed prior to and 0, 3, and 24 hours following the 91‐km mountain bike race “Nordsjørittet” (Sandnes, Norway, June 2013). There was a highly significant increase in CRP from baseline to 24 hours (0.9 (0.5‐1.8) mg/L vs. 11.6 (6.0‐17.5) mg/L (median[IQR]), <italic>P</italic><.001), with no correlation of CRP to cTnI and BNP at any time‐point. CRP was strongly correlated to race time at baseline (<italic>r</italic>=.38, <italic>P</italic><.001) and at 24 hours following the race (<italic>r</italic>=.43, <italic>P</italic><.001), In multivariate models, race time was an independent predictor of CRP both at baseline and at 24 hours (<italic>P</italic><.01). There was no relationship between CRP levels and clinical events. In conclusion, high physical fitness was associated with reduction in both basal‐ and exercise‐induced CRP. No adverse relationship was found between high intensity physical exercise, CRP levels, and outcomes.
- Subjects
NORWAY; C-reactive protein; CYCLING; PHYSICAL fitness; PROBABILITY theory; TIME; STATISTICAL significance; SPORTS events; BODY movement; NATRIURETIC peptides; TROPONIN; DESCRIPTIVE statistics; MIDDLE age
- Publication
Scandinavian Journal of Medicine & Science in Sports, 2018, Vol 28, Issue 1, p172
- ISSN
0905-7188
- Publication type
Article
- DOI
10.1111/sms.12878