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- Title
De-novo Inflammatory Bowel Disease After Bariatric Surgery: A Large Case Series.
- Authors
Neto, Manuel B. Braga; Gregory, Martin; Ramos, Guilherme P.; Loftus Jr., Edward V.; Ciorba, Matthew A.; Bruining, David H.; Bazerbachi, Fateh; Dayyeh, Barham K. Abu; Kushnir, Vladimir M.; Shah, Meera; Collazo-Clavell, Maria L.; Raffals, Laura E.; Deepak, Parakkal
- Abstract
Background: Case reports of inflammatory bowel diseases [IBD] have been reported in patients with a history of bariatric surgery. Our aim was to characterize patients who were diagnosed with IBD after having undergone bariatric surgery. Methods: Electronic medical records were reviewed at two institutions to identify patients who developed de-novo Crohn's disease or ulcerative colitis [UC] after bariatric surgery. Data on demographics, type of bariatric surgical procedure, IBD subtype, phenotype and medication usage were obtained. The incidence rate of de-novo IBD after bariatric surgery [per 100 000 personyears] and standardized incidence ratio [SIR] were estimated from a prospective bariatric surgery database. Results: A total of 44 patients with de-novo IBD after bariatric surgery were identified [31 Crohn's disease, 12 UC, one IBD unclassified]. Most patients were female [88.6%], with median age at IBD onset of 44 years [IQR, 37-52] and median time to IBD diagnosis after bariatric surgery of 7 years [IQR, 3-10]. Sixty-eight per cent underwent Roux-en-Y gastric bypass. In the prospective database, the incidence of IBD in patients who underwent bariatric surgery was 26.7 per 100 000 person-years [4.5 for UC and 22.3 for Crohn's disease]. The age-adjusted SIR ranged from 3.56 in the 40-49 year age group to 4.73 in the 30-39 year age group. Conclusion: We described a case series of patients developing de-novo IBD after bariatric surgery. There appears to be a numerically higher incidence of Crohn's disease in this population. Confirmation of causality is required in larger patient cohorts.
- Publication
Journal of Crohn's & Colitis, 2018, Vol 12, Issue 4, p452
- ISSN
1873-9946
- Publication type
Article
- DOI
10.1093/ecco-jcc/jjx177