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- Title
Development, characterization and evaluation of anti-fungal activity of miconazole based nanogel prepared from biodegradable polymer.
- Authors
Farooq, Umar; Rasul, Akhtar; Sher, Muhammed; Qadir, Muhammad Imran; Nazir, Imran; Mehmood, Yasir; Riaz, Humayun; Shah, Pervaiz Akhtar; Jamil, Qazi Adnan; Khan, Barkat A.
- Abstract
Topical candidiasis is a known skin fungal infection which is usually treated by conventional dosage forms such as cream, gel, emulgel which are having numerous adverse effects on skin. To overcome such disadvantages, different novel drug delivery systems have been considered. Polymer based nano-particulate systems have shown good skin penetration after topical application. Therefore, in the present study the main focus was on the pathology, pathogenesis, and consequently topical treatment of candidiasis. Nanogel containing miconazole have been prepared from the natural polymers i.e. gelatin and chitosan. The nanogel of miconazole (100 mg) nitrate was formulated by modified emulsification-diffusion technique and characterized for different parameters. From all the seven nanogel formulations named as F1 to F7, F1 (Gelatin and Chitosan in the percentage of 82.85 and 17.15 respectively) have been selected as model formulations. The reason behind that was as per ICH stability guideline, the formulations F1 was found optimum and stable. Miconazole nanogel formulations F1 also showed the maximum release i.e. 78 % approximately. XRD showed the formulated nanogel was in crystalline shape. In summary, the miconazole nanogel drug delivery systems have two main advantages i.e. they are topical preparation as well as nano sized. It can be postulated that nanogel may be a best approach to treat the fungal skin diseases.
- Subjects
DERMATOMYCOSES; BIOPOLYMERS; DRUG delivery systems; POLYMERS; MYCOSES; FUNGAL enzymes
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2020, Vol 33, p449
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2020.33.1.SP.449-457.1