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- Title
EFFECT OF WITHANIA SOMNIFERA EXTRACT ON MENTAL STRESS INDUCED CHANGES IN HEMODYNAMIC PROPERTIES AND ARTERIAL WAVE REFLECTIONS IN HEALTHY SUBJECTS.
- Authors
Pingali, Usharani; Pilli, Raveendranadh; Fatima, Nishat
- Abstract
Mental stress is known to contribute to the risk for hypertension and coronary atherosclerosis. Withania somnifera is well known for its anti-stress and antioxidant activity. The present study was done to assess the effect of Withania somnifera extract on acute mental stress induced changes in hemodynamics and arterial wave reflection properties in human participants. In this double-blind, placebo-controlled, randomized, crossover study, 20 healthy participants received 500 mg twice daily of an encapsulated dried aqueous extract of roots and leaves of Withania somnifera or matching placebo for 14 days with a wash out period of 14 days. Blood pressure and central arterial wave reflections were measured noninvasively using Sphygmocor before and after a standardized mental stress test. The results demonstrated an acute effect of mental stress on blood pressure and arterial wave reflections. Withania somnifera extract produced a statistically significant decrease in aortic pressure, augmentation index, radial and aortic SBP, radial and aortic DBP and significant increase in the subendocardial viability ratio (SEVR) compared to baseline and placebo. A significant decrease in hs-CRP, MDA, serum cortisol levels is seen with Withania somnifera extract treatment compared to baseline and placebo. These results suggest that beneficial properties of Withania somnifera extract can mitigate the effects of stress and deserves further investigation in patients with associated diseases.
- Subjects
PSYCHOLOGICAL stress; HEMODYNAMICS; HYPERTENSION risk factors; ATHEROSCLEROSIS risk factors; WITHANIA somnifera; PLACEBOS; PLANT extracts
- Publication
Current Topics in Nutraceutical Research, 2013, Vol 11, Issue 4, p151
- ISSN
1540-7535
- Publication type
Article