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- Title
Drug Delivery of siRNA Therapeutics.
- Authors
Lamberti, Gaetano; Barba, Anna Angela
- Abstract
Small interfering RNA (siRNA) is a class of nucleic acid-based drugs (NABDs) able to block gene expression by interaction with mRNA before its translation. The Special Issue will thus be devoted to presenting the current connections between experimental and in silico approaches for therapies based on siRNA delivery, accounting for all the most promising techniques based on liposomes, polymeric and inorganic nanoparticles, aptamers, chemical modification of siRNAs, and so on. In the reviews, different research activities cover several disciplines of investigation mainly focused on approaches of siRNA therapies to combat several kinds of cancer in laboratory conditions and the current state of siRNA-lipid delivery systems in clinical trials. After a brief description of ovarian cancer and siRNA features, they summarized the strategies employed to minimize siRNA delivery problems, the targeting strategies to ovarian cancer and the preclinical models available.
- Subjects
SMALL interfering RNA; DENDRIMERS; CANCER cell culture; NOBEL Prize in Physiology or Medicine
- Publication
Pharmaceutics, 2020, Vol 12, Issue 2, p178
- ISSN
1999-4923
- Publication type
Editorial
- DOI
10.3390/pharmaceutics12020178