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- Title
A general regression framework for group testing data, which incorporates pool dilution effects.
- Authors
Wang, Dewei; McMahan, Christopher S.; Gallagher, Colin M.
- Abstract
Group testing, through the use of pooling, has been widely implemented as a more efficient means to screen individuals for infectious diseases. Typically, in these settings, practitioners are tasked with the complimentary goals of both case identification and estimation. For these purposes, many group testing strategies have been proposed, which address issues such as preserving anonymity in estimation studies, quality control, and classification. In general, these strategies require that a significant number of the individuals be retested, either in pools or individually. In order to provide practitioners with a general methodology that can be used to accurately and precisely analyze data of this form, herein, we propose a binary regression framework that can incorporate data arising from any group testing strategy. Further, we relax previously made assumptions regarding testing error rates by relating the diagnostic testing results to the latent biological marker levels of the individuals being tested. We investigate the finite sample performance of our proposed methodology through simulation and by applying our techniques to hepatitis B data collected as part of a study involving Irish prisoners.
- Subjects
COMMUNICABLE disease diagnosis; COMPUTER simulation; MEDICAL screening; REGRESSION analysis; STATISTICS; RESEARCH bias; STATISTICAL models
- Publication
Statistics in Medicine, 2015, Vol 34, Issue 27, p3606
- ISSN
0277-6715
- Publication type
journal article
- DOI
10.1002/sim.6578