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- Title
SYNTHESIS AND BIOLOGICAL ACTIVITIES OF 3,6-DISUBSTITUTED-1,2,4-TRIAZOLO-1,3,4-THIADIAZOLE DERIVATIVES.
- Authors
Lu Lin; Hua Liu; Dun-Jia Wang; Yan-Jun Hu; Xian-Hong Wei
- Abstract
Twelve novel triazolothiadiazole derivatives were synthesized from 4-amino-5-substituted-4H-1,2,4-triazole-3-thiols with various aromatic carboxylic acids by cyclization in the presence of phosphorous oxychloride. All the newly synthesized compounds were characterized by FTIR, ¹H NMR, mass spectroscopy and elemental analysis. The antimicrobial activities of the title compounds were examined by disc diffusion method against Escherichia coli, Staphylococcus aureus, Pyricularia oryzae and Rhizoctnia solani. The bioassay indicated all synthesized triazolothiadiazole derivatives possessed moderate to good antibacterial and antifungal activities against the tested organisms. Especially, compounds 2e and 2k exhibited excellent antibacterial and antifungal activities among these triazolothiadiazole derivatives.
- Subjects
THIADIAZOLES; THIOL synthesis; ANTI-infective agents; DRUG analysis; PHENYL compounds
- Publication
Bulletin of the Chemical Society of Ethiopia, 2017, Vol 31, Issue 3, p481
- ISSN
1011-3924
- Publication type
Article
- DOI
10.4314/bcse.v31i3.12