We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism.
- Authors
Jamain, Stephane; Quach, Helene; Betancur, Catalina; Rastam, Maria; Colineaux, Catherine; Gillberg, I. Carina; Soderstrom, Henrik; Giros, Bruno; Leboyer, Marion; Gillberg, Christopher; Bourgeron, Thomas; Gillberg, Carina; Nyden, Agneta; Philippe, Anne
- Abstract
Many studies have supported a genetic etiology for autism. Here we report mutations in two X-linked genes encoding neuroligins NLGN3 and NLGN4 in siblings with autism-spectrum disorders. These mutations affect cell-adhesion molecules localized at the synapse and suggest that a defect of synaptogenesis may predispose to autism.
- Subjects
AUTISM; GENETIC mutation; ETIOLOGY of diseases; DEVELOPMENTAL disabilities; GENES
- Publication
Nature Genetics, 2003, Vol 34, Issue 1, p27
- ISSN
1061-4036
- Publication type
Article