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- Title
The Importance of Accounting for Movement When Relating Neuronal Activity to Sensory and Cognitive Processes.
- Authors
Zagha, Edward; Erlich, Jeffrey C.; Soohyun Lee; Lur, Gyorgy; O’Connor, Daniel H.; Steinmetz, Nicholas A.; Stringer, Carsen; Hongdian Yang
- Abstract
A surprising finding of recent studies in mouse is the dominance of widespread movement-related activity throughout the brain, including in early sensory areas. In awake subjects, failing to account for movement risks misattributing movementrelated activity to other (e.g., sensory or cognitive) processes. In this article, we (1) review task designs for separating taskrelated and movement-related activity, (2) review three “case studies” in which not considering movement would have resulted in critically different interpretations of neuronal function, and (3) discuss functional couplings that may prevent us from ever fully isolating sensory, motor, and cognitive-related activity. Our main thesis is that neural signals related to movement are ubiquitous, and therefore ought to be considered first and foremost when attempting to correlate neuronal activity with task-related processes.
- Subjects
SENSORIMOTOR integration; NEURAL codes; ACCOUNTING; CASE studies
- Publication
Journal of Neuroscience, 2022, Vol 42, Issue 8, p1375
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.1919-21.2021