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- Title
Serum Bilirubin Level and Aortic Intima–Media Thickness in Patients Without Clinical Manifestation of Atherosclerotic Cardiovascular Disease.
- Authors
Kalkan, Gülhan Yüksel; Gür, Mustafa; Baykan, Ahmet Oytun; Koyunsever, Nermin Yıldız; Kaypaklı, Onur; Sen, Omer; Kuloğlu, Osman; Şeker, Taner; Uçar, Hakan; Akyol, Selehattin; Elbasan, Zafer; Şahin, Durmuş Yıldıray; Çaylı, Murat
- Abstract
We investigated the association between serum bilirubin level and thoracic aortic intima–media thickness (IMT). The study population consisted of 417 patients without coronary artery disease, who underwent transesophageal echocardiography examination for various indications. The highest aortic IMT values were observed in the bilirubinlow group compared with the bilirubinhigh group (P < .001). Serum bilirubin level was associated with high-density lipoprotein cholesterol level (r = .162, P = .001), high-sensitivity C-reactive protein (hsCRP; r = −.265, P < .001), and aortic IMT (r = −.551, P < .001) in bivariate analysis. Multivariate linear regression analysis showed that serum bilirubin level was independently and negatively associated with hsCRP (β = −.095, P = .028) and aortic IMT (β = −.513, P < .001). Serum bilirubin level may be an independent predictor of the extent of subclinical aortic atherosclerosis assessed by thoracic aortic IMT.
- Subjects
ATHEROSCLEROSIS; BILIRUBIN; STATISTICAL correlation; REGRESSION analysis; STATISTICS; TRANSESOPHAGEAL echocardiography; MULTIPLE regression analysis; DATA analysis software; THORACIC aorta; SYMPTOMS
- Publication
Angiology, 2014, Vol 65, Issue 4, p308
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319713507627