We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Monocyte Chemoattractant Protein 1 Is Correlated With Glycemic Control and Peripheral Arterial Disease in Type 2 Diabetic Patients With Metabolic Syndrome.
- Authors
Papatheodorou, K.; Papanas, N.; Papazoglou, D.; Gioka, T.; Antonoglou, C.; Glaros, D.; Maltezos, E.
- Abstract
We evaluated the serum levels of monocyte chemoattractant protein 1 (MCP-1) and their association with peripheral arterial disease (PAD) in 199 patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome ([MetS], group A) in comparison with 109 healthy controls (group B). In group A, MCP-1 levels were significantly (P < .001) higher than group B and exhibited a positive correlation with HbA1c (P < .001) and a negative correlation with ankle–brachial index (P < .001). In the same group, patients with PAD had significantly higher MCP-1 levels compared with those without PAD (P < .001). In conclusion, T2DM patients with MetS exhibit higher serum MCP-1 levels. The latter is associated with worse glycemic control and PAD. These results suggest a potential contributory role for MCP-1 in the pathogenesis of PAD in the presence of hyperglycemia and MetS in T2DM.
- Subjects
GREECE; TYPE 2 diabetes complications; ACADEMIC medical centers; CHI-squared test; STATISTICAL correlation; DIABETES; INFLAMMATORY mediators; METABOLIC regulation; PERIPHERAL vascular diseases; SCALES (Weighing instruments); STATISTICS; T-test (Statistics); U-statistics; DATA analysis; METABOLIC syndrome; DATA analysis software; DESCRIPTIVE statistics; DISEASE complications
- Publication
Angiology, 2013, Vol 64, Issue 3, p223
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319712440143