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- Title
Relationship Between Plasma Inflammatory Markers and Platelet Aggregation in Patients With Clopidogrel Resistance After Angioplasty.
- Authors
Ge, Hailong; Zhou, Yujie; Liu, Xiaoli; Nie, Xiaomin; Wang, Zhijian; Guo, Yonghe; Chen, Wangjun; Yang, Qing
- Abstract
We evaluated the relationship between plasma inflammation markers and clopidogrel resistance in patients after stent implantation. The plasma levels of C-reactive protein (CRP), P-selectin, platelet soluble CD40 ligand (sCD40L), interleukin 6 (IL-6) and platelet aggregation were measured in 352 patients undergoing percutaneous coronary intervention (PCI) at baseline and after 6 months. The plasma levels of CRP, P-selectin, sCD40L, IL-6 was higher in 65 (18.5%) patients with clopidogrel resistance than in those with normal responsiveness at 6 months after PCI. There was a significant positive correlation between soluble CD40L levels and platelet aggregation (r = .28, P < .05). Diabetes (DM) and sCD40L level were independent predictors for unresponsiveness after stent implantation according to stepwise multivariate analyses. The hazard ratio (HR) for sCD40L level was 3.02 (95% CI = 1.28 to 3.25; P = .036) and for DM 2.53 (95% CI = 1.28 to 6.55, P = .03). We conclude that sCD40L and DM may influence clopidogrel resistance.
- Subjects
CORONARY heart disease prevention; CLOPIDOGREL; BIOMARKERS; BLOOD platelet aggregation; BLOOD proteins; C-reactive protein; CONFIDENCE intervals; STATISTICAL correlation; DIABETES; DRUG resistance; EPIDEMIOLOGY; INFLAMMATION; LONGITUDINAL method; MULTIVARIATE analysis; MYOCARDIAL revascularization; TRANSLUMINAL angioplasty; DATA analysis; PROPORTIONAL hazards models; DATA analysis software; DRUG-eluting stents
- Publication
Angiology, 2012, Vol 63, Issue 1, p62
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319711406432