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- Title
Serum Inflammatory and Immune Marker Response After Bare-Metal or Drug-Eluting Stent Implantation Following Percutaneous Coronary Intervention.
- Authors
Moohebati, Mohsen; Falsoleiman, Homa; Dehghani, Mashalla; Fazlinezhad, Afsoon; Daloee, Mehdi Hassanzadeh; Esmaeili, Habib; Parizadeh, Seyyed Mohammad Reza; Tavallaie, Shima; Rahsepar, Amir Ali; Paydar, Roghayeh; Kazemi-Bajestani, Seyyed Mohammad Reza; Pourghadam-Yari, Hossein; Rad, Mina Akbari; Zoghdar-Moghadam, Talat; Ghayour-Mobarhan, Majid; Ferns, Gordon A.
- Abstract
We assessed the changes in serum antiheat shock protein (HSP)-27 antibody and high-sensitivity C-reactive protein (hsCRP) levels, following the placement of a drug-eluting stent (DES) or bare-metal stent (BMS) in patients with stable coronary artery disease. Either a BMS or DES was implanted in 137 patients (82 BMS; 55 DES). Anti-HSP27 and hsCRP levels were measured 24 hours before and 24 hours after stenting. Median hsCRP serum levels increased significantly to 60.78 (10.13-84.87) and 77.80 (50.00-84.84) mg/L for BMS and DES groups (P = .006 and P = .000, respectively); this increase did not differ significantly between the 2 groups. Median anti-HSP27 antibody levels decreased to 0.26 (0.17-0.49) and 0.21 (0.16-0.29) absorbency units in BMS and DES groups (P = .045 and P = < 0.001, respectively). The changes in anti-HSP27 antibody titers were significant between the 2 groups (P = .015). Bare-metal stent and DES differ in stimulation of immune rather than inflammatory responses. Less stent restenosis after DES compared with BMS implantation could, in part, be attributed to differences in immune responses.
- Subjects
ACADEMIC medical centers; ANALYSIS of variance; C-reactive protein; COMPUTER software; CORONARY artery stenosis; ENZYME-linked immunosorbent assay; IMMUNOGLOBULINS; LIPIDS; MYOCARDIAL revascularization; STATISTICS; SURGICAL stents; T-test (Statistics); TRANSLUMINAL angioplasty; U-statistics; DATA analysis; THERAPEUTICS
- Publication
Angiology, 2011, Vol 62, Issue 2, p184
- ISSN
0003-3197
- Publication type
Article
- DOI
10.1177/0003319710375086