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- Title
Blunted day-night changes in luteinizing hormone pulse frequency in girls with obesity: the potential role of hyperandrogenemia.
- Authors
Collins, Jessicah S; Beller, Jennifer P; Burt Solorzano, Christine; Patrie, James T; Chang, R Jeffrey; Marshall, John C; McCartney, Christopher R
- Abstract
<bold>Context: </bold>Puberty is marked by sleep-associated changes in LH pulse frequency and amplitude. Early pubertal girls with obesity exhibit blunted day-to-night changes in LH secretion; whether this occurs in late pubertal obese girls is unknown.<bold>Objective: </bold>The objective of the study was to test two hypotheses: 1) blunted day-to-night changes in LH secretion occur in both early and late pubertal obese girls, and 2) such alterations are specifically associated with hyperandrogenemia.<bold>Design: </bold>This was a cross-sectional analysis.<bold>Setting: </bold>The study was conducted at a clinical research center.<bold>Patients or Other Participants: </bold>Twenty-seven early pubertal, premenarcheal girls (12 of whom were obese) and 63 late pubertal (postmenarcheal) girls (27 of whom were obese) participated in the study.<bold>Intervention: </bold>Blood samples were taken every 10 minutes from 7:00 pm to 7:00 am.<bold>Main Outcome Measure: </bold>Change in LH pulse frequency [LH interpulse interval (IPI)] from daytime hours (7:00 pm-11:00 pm, while awake) to nighttime hours (11:00 pm to 7:00 am, while generally asleep).<bold>Results: </bold>Both nonobese and obese postmenarcheal girls demonstrated significant day-to-night decreases in LH pulse frequency (IPI increases of 33% and 16%, respectively), but day-to-night changes were blunted in obese girls (P = .004, obese vs nonobese). Day-to-night LH pulse frequency decreased significantly in postmenarcheal obese subjects with normal T concentrations (26% IPI increase) but not in those with hyperandrogenemia. Similar differences were evident for LH pulse amplitude. Nonobese and obese early pubertal girls exhibited nonsignificant differences in day-night LH pulse frequency (day to night IPI increase of 26% vs decrease of 1%, respectively).<bold>Conclusions: </bold>Day-to-night changes in LH pulse secretion are blunted in postmenarcheal obese adolescent girls. This phenomenon may in part reflect hyperandrogenemia.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2014, Vol 99, Issue 8, p2887
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2013-3258