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- Title
Feasibility and Short-Term Outcomes in Liver-First Approach: A Spanish Snapshot Study (the RENACI Project).
- Authors
Serradilla-Martín, Mario; Villodre, Celia; Falgueras-Verdaguer, Laia; Zambudio-Carroll, Natalia; Castell-Gómez, José T.; Blas-Laina, Juan L.; Borrego-Estella, Vicente; Domingo-del-Pozo, Carlos; García-Plaza, Gabriel; González-Rodríguez, Francisco J.; Montalvá-Orón, Eva M.; Moya-Herraiz, Ángel; Paterna-López, Sandra; Suárez-Muñoz, Miguel A.; Alkorta-Zuloaga, Maialen; Blanco-Fernández, Gerardo; Dabán-Collado, Enrique; Gómez-Bravo, Miguel A.; Miota-de-Llamas, José I.; Rotellar, Fernando
- Abstract
Simple Summary: Current evidence does not provide enough information for selecting a tailored approach pathway in patients with colorectal cancer and synchronous liver metastases. There are no randomized clinical trials or prospective series comparing the classical approach with the liver-first approach. In addition, information on the proportion of patients who actually complete the therapeutic regimen is limited. The RENACI Project was a prospective National Registry performed on patients with colorectal cancer and synchronous liver metastases undergoing the liver-first approach. This study aimed to present the data of feasibility and short-term outcomes of the Spanish National Registry of Liver First Approach (the RENACI Project). (1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11.1%) using the liver-first approach, 63 (42.0%) in hospitals performing <50 hepatectomies/year. The proportion of patients as ASA III was significantly higher in centers performing ≥50 hepatectomies/year (difference: 18.9%; p = 0.0213). In 81.1% of the cases, the primary tumor was in the rectum or sigmoid colon. In total, 40% of the patients underwent major hepatectomies. The surgical approach was open surgery in 87 (58.0%) patients. Resection margins were R0 in 78.5% of the patients. In total, 40 (26.7%) patients had complications after the liver resection and 36 (27.3%) had complications after the primary resection. One-hundred and thirty-two (89.3%) patients completed the therapeutic regime. (4) Conclusions: There were no differences in the surgical outcomes between the centers performing <50 and ≥50 hepatectomies/year. Further analysis evaluating factors associated with clinical outcomes and determining the best candidates for this approach will be subsequently conducted.
- Subjects
LIVER surgery; LIVER tumors; RESEARCH funding; PILOT projects; COLORECTAL cancer; TREATMENT duration; TREATMENT effectiveness; CANCER patients; DESCRIPTIVE statistics; METASTASIS; CANCER chemotherapy; HEPATECTOMY; PROGRESSION-free survival
- Publication
Cancers, 2024, Vol 16, Issue 9, p1676
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16091676