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- Title
Efficacy and safety of selective internal radiation therapy with yttrium-90 for the treatment of unresectable hepatocellular carcinoma.
- Authors
Van Thai, Nguyen; Thinh, Nguyen Tien; Ky, Thai Doan; Bang, Mai Hong; Giang, Dinh Truong; Ha, Le Ngoc; Son, Mai Hong; Tien, Dao Duc; Lee, Hyun Woong
- Abstract
<bold>Background: </bold>This retrospective analysis was undertaken to evaluate the efficiency of SIRT with Y-90 microspheres and determined prognostic factors affecting patients with unresectable HCC.<bold>Methods: </bold>A total of 97 patients diagnosed with unresectable HCC who underwent SIRT with Y-90 microspheres. Patient survival was assessed using the Kaplan-Meier method, and prognostic factors affecting survival were assessed using log-rank tests and Cox proportional hazards regression.<bold>Results: </bold>Among the 97 patients (90 males, mean age 60.4 ± 12.3 years) who underwent SIRT, the median clinical follow-up was 16.4 (1.8-62) months. The median overall survival (OS) was 23.9 ± 2.4 months. Tumor response according to the Modified RECIST in patients followed up beyond 6 months included a complete response (CR) to treatment in 12 patients (18.8%), partial response (PR) in 23 (35.8%), stable disease (SD) in 8 (12.5%), and progressive disease (PD) in 21 (32.8%). Factors associated with longer OS included age > 65 years, BCLC stage B, tumor size < 5 cm, tumor burden < 25%, and tumor response (CR/PR). In multivariate analysis, unilobar disease and objective tumor response (CR/PR) were predictors of longer OS.<bold>Conclusion: </bold>SIRT was an effective treatment for unresectable HCC. Unilobar disease before SIRT and tumor response (CR/PR) were positive prognostic factors.
- Subjects
HEPATOCELLULAR carcinoma; PROGNOSIS; OVERALL survival; RADIOTHERAPY; LOG-rank test; MULTIVARIATE analysis
- Publication
BMC Gastroenterology, 2021, Vol 21, Issue 1, p1
- ISSN
1471-230X
- Publication type
journal article
- DOI
10.1186/s12876-021-01805-6