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- Title
Gut Microbiome and Cytokine Profiles in Post-COVID Syndrome.
- Authors
Mussabay, Karakoz; Kozhakhmetov, Samat; Dusmagambetov, Marat; Mynzhanova, Aitolkyn; Nurgaziyev, Madiyar; Jarmukhanov, Zharkyn; Vinogradova, Elizaveta; Dusmagambetova, Aigul; Daulbaeva, Aiganym; Chulenbayeva, Laura; Tauekelova, Ainur; Bekbossynova, Makhabbat; Kushugulova, Almagul
- Abstract
Recent studies highlight the crucial role of the gut microbiome in post-infectious complications, especially in patients recovering from severe COVID-19. Our research aimed to explore the connection between gut microbiome changes and the cytokine profile of patients with post-COVID syndrome. Using 16S rRNA amplicon sequencing, we analyzed the composition of the gut microbiome in 60 COVID-19 patients over the course of one year. We also measured the levels of serum cytokines and chemokines using the Milliplex system. Our results showed that severe SARS-CoV-2 infection cases, especially those complicated by pneumonia, induce a pro-inflammatory microbial milieu with heightened presence of Bacteroides, Faecalibacterium, and Prevotella_9. Furthermore, we found that post-COVID syndrome is characterized by a cross-correlation of various cytokines and chemokines MDC, IL-1b, Fractalkine, TNFa, FGF-2, EGF, IL-1RA, IFN-a2, IL-10, sCD40L, IL-8, Eotaxin, IL-12p40, and MIP-1b as well as a shift in the gut microbiome towards a pro-inflammatory profile. At the functional level, our analysis revealed associations with post-COVID-19 in homolactic fermentation, pentose phosphate, NAD salvage, and flavin biosynthesis. These findings highlight the intricate interplay between the gut microbiota, their metabolites, and systemic cytokines in shaping post-COVID symptoms. Unraveling the gut microbiome's role in post-infectious complications opens avenues for new treatments for those patients with prolonged symptoms.
- Subjects
POST-acute COVID-19 syndrome; GUT microbiome; COVID-19; MICROBIAL metabolites; FRACTALKINE; CYTOKINES; POST-infectious disorders
- Publication
Viruses (1999-4915), 2024, Vol 16, Issue 5, p722
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v16050722