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- Title
Efficient Dynamic Nuclear Polarization at 800 MHz/527 GHz with Trityl-Nitroxide Biradicals.
- Authors
Mathies, Guinevere; Caporini, Marc A.; Michaelis, Vladimir K.; Liu, Yangping; Hu, Kan ‐ Nian; Mance, Deni; Zweier, Jay L.; Rosay, Melanie; Baldus, Marc; Griffin, Robert G.
- Abstract
Cross-effect (CE) dynamic nuclear polarization (DNP) is a rapidly developing technique that enhances the signal intensities in magic-angle spinning (MAS) NMR spectra. We report CE DNP experiments at 211, 600, and 800 MHz using a new series of biradical polarizing agents referred to as TEMTriPols, in which a nitroxide (TEMPO) and a trityl radical are chemically tethered. The TEMTriPol molecule with the optimal performance yields a record 1H NMR signal enhancement of 65 at 800 MHz at a concentration of 10 m M in a glycerol/water solvent matrix. The CE DNP enhancement for the TEMTriPol biradicals does not decrease as the magnetic field is increased in the manner usually observed for bis-nitroxides. Instead, the relatively strong exchange interaction between the trityl and nitroxide moieties determines the magnetic field at which the optimum enhancement is observed.
- Subjects
DYNAMIC nuclear polarisation; BIRADICALS; MAGIC angle spinning; TETHERED particle motion; NITROXIDE derivatives; NUCLEAR magnetic resonance spectroscopy; ELECTRON paramagnetic resonance
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 40, p11936
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201504292