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- Title
Vek ako potenciálny faktor ovplyvňujúci patologické ukazovatele a prognózu ochorenia u pacientov s karcinómom obličky.
- Authors
Bartoš, V.; Mráz, R.; Mikuláš, J.; Laurinc, P.
- Abstract
Background: Renal cell carcinoma (RCC) represents a heterogeneous group of oncological entities, which are characterized by some age-related differences as well. Aim: The purpose of our study was to investigate the differences in the pathological parameters of renal cell carcinoma in relation to age of patients. Material and methods: The study included 143 representative RCC cases from 141 subjects (88 males, 53 females) between 18-82 years of age. Based on the age, they were stratified into 3 groups: group A (≤ 40 years), group B (41-60 years), and group C (≥ 61 years). Results: In group A, B and C, we registered 4 (2.8 %), 47 (33.4 %) and 90 (63.8 %) patients, respectively. In the youngest group, there were only conventional clear cell RCCs. In group B and C, conventional clear cell RCC predominated (81.2 % vs. 80.2 %) and percentage of the individual histological cancer types was about the same. As age increased, mean tumor size was larger (2.5 vs. 4.5 vs. 5.2 cm), percentage of stage pT1a decreased (100 % vs. 50 % vs. 35.1 %), percentage of stage pT1b (0 % vs. 18.7 % vs. 26.4 %) and pT3 (0 % vs. 25 % vs. 34.1 %) increased, Fuhrman nuclear grade 4 was more frequent (0 % vs. 14.6 % vs. 26.4 %), number of cases with regional lymph node metastasis increased (0 % vs. 6.2 % vs. 8.8 %) and necrotic (0 % vs. 35.4 % vs. 41.7 %) and sarcomatoid (0 % vs. 4.1 % vs. 13.2 %) tumor changes occurred more commonly. Conclusion: Our study showed, that depending on the age group, there were some differences in several pathological parameters. In general, unfavourable variables predominated in the oldest group. Whether these parameters directly reflect a different prognosis of disease in relation to age of the patients remains questionable.
- Subjects
RENAL cell carcinoma; LYMPH nodes; CANCER research; METASTASIS; ONCOLOGY
- Publication
General Practitioner / Praktický Lékař, 2012, Vol 92, Issue 6, p330
- ISSN
0032-6739
- Publication type
Article