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- Title
The Role of α-Synuclein and LRRK2 in Tau Phosphorylation.
- Authors
Kawakami, Fumitaka; Ichikawa, Takafumi
- Abstract
There is now a considerable body of experimental evidence that Parkinson’s disease arises through physiological interaction of causative molecules, leading to tau pathology. In this review, we discuss the physiological role of α-synuclein and LRRK2 in the abnormal phosphorylation of tau. In addition, as recent reports have indicated that heat shock proteins- (HSPs-) inducing drugs can help to ameliorate neurodegenerative diseases associated with tau pathology, we also discuss therapeutic strategies for PD focusing on inhibition of α-synuclein- and LRRK2-associated tau phosphorylation by HSPs.
- Subjects
PARKINSON'S disease; PHOSPHORYLATION; RESEARCH funding
- Publication
Parkinson's Disease (20420080), 2015, Vol 2015, p1
- ISSN
2090-8083
- Publication type
Article
- DOI
10.1155/2015/734746