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- Title
Catalytic Access to Alkyl Bromides, Chlorides and Iodides via Visible Light-Promoted Decarboxylative Halogenation.
- Authors
Candish, Lisa; Standley, Eric A.; Gómez‐Suárez, Adrián; Mukherjee, Satobhisha; Glorius, Frank
- Abstract
Herein is reported the catalytic, visible light-promoted, decarboxylative halogenation (bromination, chlorination, and iodination) of aliphatic carboxylic acids. This operationally-simple reaction tolerates a range of functional groups, proceeds at room temperature, and is redox neutral. By employing an iridium photocatalyst in concert with a halogen atom source, the use of stoichiometric metals such as silver, mercury, thallium, and lead can be circumvented. This reaction grants access to valuable synthetic building blocks from the large pool of cheap, readily available carboxylic acids.
- Subjects
ALKYL bromides; ORGANOBROMINE compounds; HALOGENATION; CHEMICAL reactions; CARBOXYLIC acids
- Publication
Chemistry - A European Journal, 2016, Vol 22, Issue 29, p9971
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201602251