We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Preclinical Cancer Theranostics—From Nanomaterials to Clinic: The Missing Link.
- Authors
Johnson, Kochurani K.; Koshy, Pramod; Yang, Jia‐Lin; Sorrell, Charles C.
- Abstract
Nanomaterials with cancer‐imaging and therapeutic properties have emerged as the principal focus of nanotheranostics. The past decade has experienced a significant increase in research in the design, formulation, and preclinical and clinical trials of theranostic nanosystems. However, current theranostic nanoformulations have yet to be approved by the FDA for clinical use. Consequently, the present review focuses on the importance of the careful examination of the in vivo preclinical status of specific nanotheranostic materials as a prerequisite for their clinical translation. The scope of coverage is structured according to all of the major organic, inorganic, 2D, and hybrid nanotheranostic materials and their in vivo preclinical status. The therapeutic advantages and limitations of these materials in animal models are considered and the various strategies to enhance the biocompatibility of theranostic nanoparticles are summarized.
- Subjects
UNITED States. Food &; Drug Administration; COMPANION diagnostics; NANOSTRUCTURED materials; CLINICAL trials; TRANSLATING &; interpreting; EXPERIMENTAL design; PHOTOVOLTAIC power systems; CLINICS
- Publication
Advanced Functional Materials, 2021, Vol 31, Issue 43, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202104199