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- Title
Diagnostic value of MRI-based 3D texture analysis for tissue characterisation and discrimination of low-grade chondrosarcoma from enchondroma: a pilot study.
- Authors
Lisson, Catharina S.; Lisson, Christoph G.; Flosdorf, Kerstin; Mayer-Steinacker, Regine; Schultheiss, Markus; von Baer, Alexandra; Barth, Thomas F. E.; Beer, Ambros J.; Baumhauer, Matthias; Meier, Reinhard; Beer, Meinrad; Schmidt, Stefan A.
- Abstract
<bold>Objectives: </bold>To explore the diagnostic value of MRI-based 3D texture analysis to identify texture features that can be used for discrimination of low-grade chondrosarcoma from enchondroma.<bold>Methods: </bold>Eleven patients with low-grade chondrosarcoma and 11 patients with enchondroma were retrospectively evaluated. Texture analysis was performed using mint Lesion: Kurtosis, entropy, skewness, mean of positive pixels (MPP) and uniformity of positive pixel distribution (UPP) were obtained in four MRI sequences and correlated with histopathology. The Mann-Whitney U-test and receiver operating characteristic (ROC) analysis were performed to identify most discriminative texture features. Sensitivity, specificity, accuracy and optimal cut-off values were calculated.<bold>Results: </bold>Significant differences were found in four of 20 texture parameters with regard to the different MRI sequences (p<0.01). The area under the ROC curve values to discriminate chondrosarcoma from enchondroma were 0.876 and 0.826 for kurtosis and skewness in contrast-enhanced T1 (ceT1w), respectively; in non-contrast T1, values were 0.851 and 0.822 for entropy and UPP, respectively. The highest discriminatory power had kurtosis in ceT1w with a cut-off ≥3.15 to identify low-grade chondrosarcoma (82 % sensitivity, 91 % specificity, accuracy 86 %).<bold>Conclusion: </bold>MRI-based 3D texture analysis might be able to discriminate low-grade chondrosarcoma from enchondroma by a variety of texture parameters.<bold>Key Points: </bold>• MRI texture analysis may assist in differentiating low-grade chondrosarcoma from enchondroma. • Kurtosis in the contrast-enhanced T1w has the highest power of discrimination. • Tools provide insight into tumour characterisation as a non-invasive imaging biomarker.
- Subjects
TUMOR markers; CHONDROSARCOMA; ENCHONDROMA; HISTOPATHOLOGY; KURTOSIS
- Publication
European Radiology, 2018, Vol 28, Issue 2, p468
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-5014-6