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- Title
Multimodality imaging features of USP6-associated neoplasms.
- Authors
Broski, Stephen M.; Wenger, Doris E.
- Abstract
Since the discovery of USP6 gene rearrangements in aneurysmal bone cysts nearly 20 years ago, we have come to recognize that there is a family of USP6-driven mesenchymal neoplasms with overlapping clinical, morphologic, and imaging features. This family of neoplasms now includes myositis ossificans, aneurysmal bone cyst, nodular fasciitis, fibroma of tendon sheath, fibro-osseous pseudotumor of digits, and their associated variants. While generally benign and in many cases self-limiting, these lesions may undergo rapid growth, and be confused with malignant bone and soft tissue lesions, both clinically and on imaging. The purpose of this article is to review the imaging characteristics of the spectrum of USP6-driven neoplasms, highlight key features that allow distinction from malignant bone or soft tissue lesions, and discuss the role of imaging and molecular analysis in diagnosis.
- Subjects
ANEURYSMAL bone cyst; FIBRODYSPLASIA ossificans progressiva; NODULAR fasciitis; FIBROMAS; CLINICAL trials
- Publication
Skeletal Radiology, 2023, Vol 52, Issue 3, p297
- ISSN
0364-2348
- Publication type
Article
- DOI
10.1007/s00256-022-04146-x