We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine.
- Authors
Taipale, Jussi; Chen, James K.; Cooper, Michael K.; Wang, Baolin; Mann, Randall K.; Milenkovic, Ljiljana; Scott, Matthew P.; Beachy, Philip A.
- Abstract
Discusses the use of the plant-derived teratogen cyclopamine as a treatment for certain types of tumors, such as basal cell carcinoma and rhabdomyosarcoma. Involvement of the Hedgehog (Hh) response in the development of tumors; Results of tests on the use of cyclopamine to block activation of the Hh response and abnormal cell growth.
- Subjects
TUMOR treatment; TERATOGENIC agents; CANCER treatment; CELLS; CANCER; THERAPEUTICS
- Publication
Nature, 2000, Vol 406, Issue 6799, p1005
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/35023008