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- Title
A mammalian protein with specific demethylase activity for mCpG DNA.
- Authors
Bhattacharya, Sanjoy K.; Ramchandani, Shyam; Cervoni, Nadia; Szyf, Moshe
- Abstract
Reports the cloning of a gene which codes for a mammalian protein with the ability to catalyse demethylation by directly removing methyl groups from 5-methyl-cytosine residues in DNA. Importance of DNA-methylation patterns for regulating genome functions; How a complementary DNA encoldes a methyl-CpG-binding domain; Identification of a DNA-demethylase candidate; Demethylation activity of the translated candidate cDNA.
- Subjects
GENE expression; CLONING; GENES; MAMMALS; DNA-binding proteins; SCIENTIFIC experimentation; GENETICS; IDENTIFICATION
- Publication
Nature, 1999, Vol 397, Issue 6720, p579
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/17533